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Our systematic review identified 12 orders of wild-caught vertebrates and seven mosquito genera with evidence of MAYV occurrence. MAYV positivity was reported in 12 orders of wild-caught vertebrates, most frequently in the orders Charadriiformes and Primate. Seventeen studies reported MAYV positivity in wild mammals, birds, or reptiles and five studies reported MAYV positivity in domestic animals. Overall, 57 studies were eligible out of 1523 screened, published between the years 19. We conducted a georeferenced, quality-graded systematic review to evaluate the current evidence regarding MAYV occurrence in non-human vertebrates and arthropods. Mayaro virus (MAYV) is an emerging tropical public health threat in the Americas.
#FREEMAN TUKEY DOUBLE ARCSINE TRANSFORMATION IN R DRIVERS#
These findings support further risk emergence prediction, guide field surveillance efforts, and prompt further in-vivo studies to better define the ecological drivers of MAYV maintenance and potential for emergence. The quality of evidence behind these findings was variable and prompts calls for standardization of reporting of arbovirus occurrence. We further found that MAYV occurs in a wide range of vectors beyond Haemagogus spp. From the three most studied primate genera we found the highest seroprevalence was in Alouatta (32.2%, 95% CI: 0.0–79.2%), followed by Callithrix (17.8%, 95% CI: 8.6–28.5%), and Cebus/Sapajus (3.7%, 95% CI: 0.0–11.1%). Among non-human vertebrates, the Primate order had the highest pooled seroprevalence at 13.1% (95% CI: 4.3–25.1%). Vertebrate animals or arthropods with MAYV were detected in Brazil, Panama, Peru, French Guiana, Colombia, Trinidad, Venezuela, Argentina, and Paraguay. Sixteen studies detected MAYV in wild-caught mosquito genera including Haemagogus, Aedes, Culex, Psorophora, Coquillettidia, and Sabethes. We compiled granular georeferenced maps of non-human MAYV occurrence and graded the quality of the studies using a customized framework. We conducted an animal seroprevalence meta-analysis using a random effects model. Studies were included if they assessed MAYV virological/immunological measured occurrence in field-caught, domestic, or sentinel animals or in field-caught arthropods. We searched PubMed/MEDLINE, Embase, Web of Science, SciELO and grey-literature sources including PAHO databases and dissertation repositories. We conducted a PRISMA-adherent systematic review of the published and grey literature to identify potential arthropod vectors and non-human animal reservoirs of MAYV. Improving our understanding of Mayaro virus (MAYV) ecology is critical to guide surveillance and risk assessment.